Anticorps Polyclonal de lapin anti-COL4A5

COL4A5 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IHC, IF, ELISA

Conjugaison

Non conjugué

Publications(17)

N° de cat : 19797-1-AP

Synonymes

Collagen alpha 5(IV) chain, Collagen alpha-5(IV) chain

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Galerie de données de validation

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Applications publiées

• WB: See 13 publications below
• IHC: See 2 publications below
• IF: See 4 publications below

Informations sur le produit

19797-1-AP cible COL4A5 dans les applications de WB, IHC, IF, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: collagen, type IV, alpha 5
• Masse moléculaire calculée: 161 kDa
• Numéro d’acquisition GenBank: NM_000495
• Symbole du gène: COL4A5
• Identification du gène (NCBI): 1287
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

COL4A5 belongs to the type IV collagen family. Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A5 are the cause of Alport syndrome X-linked (APSX). Deletions covering the N-terminal regions of COL4A5 and COL4A6, which are localized in a head-to-head manner, are the cause of diffuse leiomyomatosis with Alport syndrome (DL-ATS)which also known as esophageal and vulval leiomyomatosis with nephropathy or Alport syndrome and diffuse leiomyomatosis (ATS-DL).

Publications

Species	Application	Title
mouse	IF	Biomaterials; A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.; Authors - Wei Yang
mouse	WB	PLoS Genet; Minor Type IV Collagen α5 Chain Promotes Cancer Progression through Discoidin Domain Receptor-1.; Authors - Qian Xiao
human	WB	FASEB J; Drastic induction of MMP-7 by cortisol in the human amnion: implications for membrane rupture at parturition.; Authors - Lu-Yao Wang
mouse	WB	Bioorg Chem; AT1, a small molecular degrader of BRD4 based on proteolysis targeting chimera technology alleviates renal fibrosis and inflammation in diabetic nephropathy; Authors - Meng Yang
mouse	IF	Sci Rep; Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.; Authors - Yahui Ren
mouse	WB	Front Pharmacol; Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway; Authors - Zhe Wang

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