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Anticorps Polyclonal de lapin anti-COL6A3

COL6A3 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 19798-1-PBS

Synonymes

Collagen alpha 3(VI) chain, Collagen alpha-3(VI) chain, Collagen Type VI

Galerie de données de validation

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  • Immunohistochemistry (IHC) staining of human cervical cancer tissue using COL6A3 Polyclonal antibody (19798-1-AP)

    IHC staining of human cervical cancer using 19798-1-AP (same clone as 19798-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using COL6A3 Polyclonal antibody (19798-1-AP)

    IHC staining of human lung cancer using 19798-1-AP (same clone as 19798-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human urothelial carcinoma tissue using COL6A3 Polyclonal antibody (19798-1-AP)

    IHC staining of human urothelial carcinoma using 19798-1-AP (same clone as 19798-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human urothelial carcinoma tissue slide using 19798-1-AP (Collagen Type VI antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19798-1-PBS in a different storage buffer formulation.

Informations sur le produit

19798-1-PBS cible COL6A3 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet collagen, type VI, alpha 3
Masse moléculaire calculée 344 kDa
Poids moléculaire observé300 kDa
Numéro d’acquisition GenBankNM_004369
Symbole du gène COL6A3
Identification du gène (NCBI) 1293
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

COL6A3 belongs to the type VI collagen family. Collagen VI acts as a cell-binding protein. It is expected to be expressed in smooth muscle. And the calculated molecular weight of COL6A3 is 343 kDa. The protein has similar expression in obese and T2DM (2 patients, and it regulates the chemotaxis and inflammation of macrophages in adipose tissue. Its expression is also related to weight gain. The expression of this protein in adipocytes is related to insulin resistance, which is believed to depend on PPAR (peroxisome proliferator-activated receptor) α-mediated adipocyte development (PMID: 25337653). Defects in COL6A3 are a cause of Bethlem myopathy (BM). Defects in COL6A3 are a cause of Ullrich congenital muscular dystrophy (UCMD) which also known as Ullrich scleroatonic muscular dystrophy. This antibody is specific to COL6A3.

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