Anticorps Monoclonal anti-COMMD5

COMMD5 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1E10G6

N° de cat : 67043-1-PBS

Synonymes

COMM domain containing 5, COMMD5, FLJ13008, HCARG, HT002

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Galerie de données de validation

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  WB analysis of human heart using 67043-1-Ig (same clone as 67043-1-PBS)

  human heart tissue were subjected to SDS PAGE followed by western blot with 67043-1-Ig (COMMD5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67043-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat heart using 67043-1-Ig (same clone as 67043-1-PBS)

  rat heart tissue were subjected to SDS PAGE followed by western blot with 67043-1-Ig (COMMD5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67043-1-PBS in a different storage buffer formulation.

• 

  WB analysis of MCF-7 using 67043-1-Ig (same clone as 67043-1-PBS)

  MCF-7 cells were subjected to SDS PAGE followed by western blot with 67043-1-Ig (COMMD5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67043-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293 using 67043-1-Ig (same clone as 67043-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 67043-1-Ig (COMMD5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67043-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67043-1-PBS cible COMMD5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: COMMD5 Protéine recombinante Ag18464
• Nom complet: COMM domain containing 5
• Masse moléculaire calculée: 25 kDa
• Poids moléculaire observé: 15 kDa
• Numéro d’acquisition GenBank: BC003055
• Symbole du gène: COMMD5
• Identification du gène (NCBI): 28991
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

COMM domain containing 5 (COMMD5, synonyms: HCARG, HT002) is a hypertension-related calcium-regulated gene. COMMD5 is negatively regulated by extracellular calcium concentration, and its basal mRNA levels were higher in hypertensive animals. Tissue distribution of COMMD5 shows a preponderance in the heart, stomach, jejunum, kidney (tubular fraction), liver, and adrenal gland (mainly in the medulla). COMMD5 mRNA is significantly more expressed in adult than in fetal organs, and its levels are decreased in tumors and cancerous cell lines. COMMD5 protein has no transmembrane domain, but contains 67% -helix content, a calcium-binding site, four putative "leucine zipper" motifs, and a nuclear receptor-binding domain. At the subcellular level, COMMD5 shows a nuclear localization.

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