Anticorps Recombinant de lapin anti-COQ5

COQ5 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250140E11

N° de cat : 85890-1-PBS

Synonymes

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, EC:2.1.1.201, Ubiquinone biosynthesis methyltransferase COQ5

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Galerie de données de validation

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  WB analysis using 85890-1-RR (same clone as 85890-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85890-1-RR (COQ5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85890-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85890-1-PBS cible COQ5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: COQ5 Protéine recombinante Ag10203
• Nom complet: coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
• Masse moléculaire calculée: 327 aa, 37 kDa
• Poids moléculaire observé: 32 kDa
• Numéro d’acquisition GenBank: BC107874
• Symbole du gène: COQ5
• Identification du gène (NCBI): 84274
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

COQ5 catalyzes the only C-methylation involved in the biosynthesis of coenzyme Q (Q or ubiquinone) in humans and yeast Saccharomyces cerevisiae. In humans, mutations in several COQ genes cause primary Q deficiency, and a decrease in Q biosynthesis is associated with mitochondrial, cardiovascular, kidney and neurodegenerative diseases (PMID: 25152161). Endogenous human COQ5 protein primarily existed as a mature form (m-COQ5, ~32 kDa) without the mitochondrial targeting sequence (MTS) in the mitochondria of human cells, in addition to the minor precursor form (p-COQ5, 37 kDa) of the full-length protein (PMID: 27155576).

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