Anticorps Polyclonal de lapin anti-CPLX2

CPLX2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20249-1-PBS

Synonymes

---

Galerie de données de validation

• 

  WB analysis of mouse brain using 20249-1-AP (same clone as 20249-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 20249-1-AP (CPLX2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20249-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human brain using 20249-1-AP (same clone as 20249-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human brain slide using 20249-1-AP (CPLX2 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 20249-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

20249-1-PBS cible CPLX2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: complexin 2
• Masse moléculaire calculée: 15 kDa
• Poids moléculaire observé: 20 kDa
• Numéro d’acquisition GenBank: NM_006650
• Symbole du gène: CPLX2
• Identification du gène (NCBI): 10814
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Neuronal specific complexin 1 (CPLX1) has inhibitory and stimulatory effects on exocytosis by clamping trans-SNARE complexes in a prefusion state and promoting conformational changes to facilitate membrane fusion following cell stimulation. Complexin2 (CPLX2) is a pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals, it is downregulated in schizophrenic patients suffering from depression, animal models of depression and neurological disorders such as Huntington's disease in which depression is a major symptom. This antibody is expected to specifically recogize CPLX2 but not other complexins.

{{ptg:RelatedPrimaryAntibodies}}