Anticorps Polyclonal de lapin anti-CREB5

• Phare
• Validé par KD/KO

CREB5 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 14196-1-PBS

Synonymes

CRE-BPa, CREBPA, CREB-5, CREB 5, cAMP-responsive element-binding protein 5

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Galerie de données de validation

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  WB analysis of HepG2 using 14196-1-AP (same clone as 14196-1-PBS)

  HepG2 cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 14196-1-AP (same clone as 14196-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

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  WB analysis of MCF-7 using 14196-1-AP (same clone as 14196-1-PBS)

  MCF7 cells were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

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  WB analysis of human brain using 14196-1-AP (same clone as 14196-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 14196-1-AP (CREB5 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14196-1-PBS in a different storage buffer formulation.

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Informations sur le produit

14196-1-PBS cible CREB5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CREB5 Protéine recombinante Ag5399
• Nom complet: cAMP responsive element binding protein 5
• Masse moléculaire calculée: 57 kDa
• Poids moléculaire observé: 57 kDa
• Numéro d’acquisition GenBank: BC059400
• Symbole du gène: CREB5
• Identification du gène (NCBI): 9586
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

cyclic AMP responsive element binding protein 5 (CREB5), also known as CRE-BPA, a member of the cAMP response element binding protein family, is a transcription factor specifically expressed in superficial zone articular chondrocytes and is required for TGF-β and EGFR signaling. Knockdown of CREB5 decreased the c-jun and c-fos expression levels in HC-a cells (PMID: 38549717). Increased CREB5 expression is positively correlated with tumor cell invasion and a poor prognosis for cancer patients with epithelial ovarian cancer and hepatocellular carcinoma (PMID: 38418476).This protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified (PMID: 33712729).

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