Anticorps Recombinant de lapin anti-CSF1R/CD115

CSF1R/CD115 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250001D7

N° de cat : 98379-3-RR

Synonymes

CSF1R, C FMS, CD115, CSF 1 R, CSF-1 receptor

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Galerie de données de validation

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  FC experiment of human PBMCs using 98379-3-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CSF1R/CD115 Rabbit RecAb (98379-3-RR, Clone:250001D7) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

• 

  FC experiment of human PBMCs using 98379-3-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human CSF1R/CD115 Rabbit RecAb (98379-3-RR, Clone: 250001D7) (red) or Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

• 

  Affinity and Kinetic Characterization of 98379-3-RR

  Biolayer interferometry (BLl) kinetic assays of 98379-3-RR against Human CSF1R/CD115 were performed. The affinity constant is 1.62 nM.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98379-3-RR cible CSF1R/CD115 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: colony stimulating factor 1 receptor
• Masse moléculaire calculée: 972 aa, 108 kDa
• Numéro d’acquisition GenBank: BC047521
• Symbole du gène: CSF1R/CD115
• Identification du gène (NCBI): 1436
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

The CSF-1 receptor (CSF1R), also called CD115, is activated by the homodimeric growth factors colony-stimulating factor-1 (CSF-1) and interleukin-34 (IL-34). It plays important roles in development and in innate immunity by regulating the development of most tissue macrophages and osteoclasts, of Langerhans cells of the skin, of Paneth cells of the small intestine, and of brain microglia. It also regulates the differentiation of neural progenitor cells and controls functions of oocytes and trophoblastic cells in the female reproductive tract. Owing to this broad tissue expression pattern, it plays a central role in neoplastic, inflammatory, and neurological diseases.

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