Anticorps Recombinant de lapin anti-IL-3RB/CD131

IL-3RB/CD131 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241954C1

N° de cat : 98232-1-PBS

Synonymes

241954C1, Aic2b, CD131, Csf2rb, Csf2rb1

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Galerie de données de validation

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  FC experiment of mouse bone marrow cells using 98232-1-RR (same clone as 98232-1-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse IL-3RB/CD131 Rabbit RecAb (98232-1-RR, Clone: 241954C1) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with APC Anti-Mouse CD11b (M1/70) (APC-65055, Clone: M1/70). Cells were not fixed. This data was developed using the same antibody clone with 98232-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse bone marrow cells using 98232-1-RR (same clone as 98232-1-PBS)

  1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse IL-3RB/CD131 Rabbit RecAb (98232-1-RR, Clone: 241954C1) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98232-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98232-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98232-1-RR against Mouse IL-3RB/CD131 were performed. The affinity constant is below 1 pM.

• 

  Affinity and Kinetic Characterization of 98232-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98232-1-RR against Mouse IL-3RB/CD131 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

98232-1-PBS cible IL-3RB/CD131 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: IL-3RB/CD131 Protéine recombinante Eg2173
• Nom complet: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
• Masse moléculaire calculée: 99kDa
• Numéro d’acquisition GenBank: NM_007780.4
• Symbole du gène: IL-3RB/CD131
• Identification du gène (NCBI): 12983
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

CD131, also known as IL-3RB, IL-5RB, colony stimulating factor 2 receptor subunit beta (CSF2RB), or cytokine receptor common subunit beta, is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3 and IL-5 (PMID: 36532080). It is expressed predominantly by hematopoietic cells but also by non-hematopoietic cells (PMID: 10582335). CD131 mediates intracellular signaling by JAK2, leading to phosphorylation of CD131 and triggering signaling pathways such as STAT5, MAPK and PI3-Kinase/AKT which regulate cell survival, proliferation and function (PMID: 23535386).

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