Anticorps Polyclonal de lapin anti-CTNNAL1

• Phare
• Validé par KD/KO

CTNNAL1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32926-1-PBS

Synonymes

ACRP, Alpha catenin related protein, alpha CATU, Alpha catulin, Alpha-catenin-related protein

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Galerie de données de validation

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  WB analysis using 32926-1-AP (same clone as 32926-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32926-1-AP (CTNNAL1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32926-1-PBS in a different storage buffer formulation.

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  WB analysis of HepG2 using 32926-1-AP (same clone as 32926-1-PBS)

  WB result of CTNNAL1 antibody (32926-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-CTNNAL1 transfected HepG2 cells. This data was developed using the same antibody clone with 32926-1-PBS in a different storage buffer formulation.

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Informations sur le produit

32926-1-PBS cible CTNNAL1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CTNNAL1 Protéine recombinante Ag38629
• Nom complet: catenin (cadherin-associated protein), alpha-like 1
• Masse moléculaire calculée: 82 kDa
• Poids moléculaire observé: 82 kDa
• Numéro d’acquisition GenBank: NM_003798
• Symbole du gène: CTNNAL1
• Identification du gène (NCBI): 8727
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Catenin alpha-like protein 1 (CTNNAL1, also known as alpha-catulin) is a cytoplasmic molecule that integrates the crosstalk between nuclear factor-kappa B (NF-κB) and Rho signaling pathways. It plays a crucial role in maintaining epithelial integrity and promoting wound repair in bronchial epithelial cells. CTNNAL1 has been shown to inhibit ozone-induced airway epithelial-mesenchymal transition and regulate mucus hypersecretion induced by house dust mite (HDM) (PMID: 38602002). Additionally, CTNNAL1 promotes the structural integrity of bronchial epithelial cells through the RhoA/ROCK1 pathway (PMID: 36535402). In cancer, CTNNAL1 regulates cancer stem cells (CSCs) in lung cancer and glioblastoma, modulating their migration and invasion abilities (PMID: 37239133).

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