Anticorps Polyclonal de lapin anti-CUL2

CUL2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30071-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 30071-1-AP (same clone as 30071-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30071-1-AP (CUL2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30071-1-PBS in a different storage buffer formulation.

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  WB analysis of PC-3 using 30071-1-AP (same clone as 30071-1-PBS)

  WB result of CUL2 antibody (30071-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-CUL2 transfected PC-3 cells. This data was developed using the same antibody clone with 30071-1-PBS in a different storage buffer formulation.

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Informations sur le produit

30071-1-PBS cible CUL2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CUL2 Protéine recombinante Ag32331
• Nom complet: cullin 2
• Masse moléculaire calculée: 87 kDa
• Poids moléculaire observé: 80-87 kDa
• Numéro d’acquisition GenBank: BC009591
• Symbole du gène: CUL2
• Identification du gène (NCBI): 8453
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The cullin family proteins are scaffold proteins for the Ring finger type E3 ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Humans express seven cullin proteins: CUL1-3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. The Cullin-RING-finger type E3 ligases are important regulators in early embryonic development, as highlighted by genetic studies demonstrating that knock-out of CUL1, CUL3, or CUL4A in mice results in early embryonic lethality.

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