Anticorps Monoclonal anti-CXCL8/IL8
CXCL8/IL8 Monoclonal Antibody for ELISA
Hôte / Isotype
Mouse / IgG2a
Réactivité testée
Humain
Applications
WB, IHC, ELISA
Conjugaison
Non conjugué
CloneNo.
3D11D5
N° de cat : 60141-2-Ig
Synonymes
Galerie de données de validation
Applications testées
Dilution recommandée
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Applications publiées
| WB | See 3 publications below |
| IHC | See 3 publications below |
| ELISA | See 1 publications below |
Informations sur le produit
60141-2-Ig cible CXCL8/IL8 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Réactivité citée | Humain |
| Hôte / Isotype | Mouse / IgG2a |
| Clonalité | Monoclonal |
| Type | Anticorps |
| Immunogène | CXCL8/IL8 Protéine recombinante Ag10552 |
| Nom complet | interleukin 8 |
| Masse moléculaire calculée | 99 aa, 11 kDa |
| Numéro d’acquisition GenBank | BC013615 |
| Symbole du gène | IL8 |
| Identification du gène (NCBI) | 3576 |
| Conjugaison | Non conjugué |
| Forme | Liquide |
| Méthode de purification | Purification par protéine A |
| Tampon de stockage | PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3 |
| Conditions de stockage | Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA. |
Informations générales
Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa).
Publications
| Species | Application | Title |
|---|---|---|
Aging Cell Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. | ||
Front Immunol Ultraviolet B Inhibits IL-17A/TNF-α-Stimulated Activation of Human Dermal Fibroblasts by Decreasing the Expression of IL-17RA and IL-17RC on Fibroblasts. | ||
PLoS One Pseudomonas-Derived Ceramidase Induces Production of Inflammatory Mediators from Human Keratinocytes via Sphingosine-1-Phosphate. | ||
Cancer Med Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. | ||
Oncogene Targeting epiregulin in the treatment-damaged tumor microenvironment restrains therapeutic resistance |
