Anticorps Monoclonal anti-CXCL8/IL-8

CXCL8/IL-8 Monoclonal Antibody for Sandwich ELISA, Indirect ELISA, Sample test

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

Sandwich ELISA, Indirect ELISA, Sample test

Conjugaison

Non conjugué

CloneNo.

3D11D5

N° de cat : 60141-2-PBS

Synonymes

CXCL8, IL8, IL-8, C-X-C motif chemokine 8, C-X-C motif

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Galerie de données de validation

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  Sandwich ELISA standard curve of MP50089-1

  Sandwich ELISA standard curve of MP50089-1, CXCL8/IL-8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 68744-1-PBS. Detection antibody: HRP-conjugated 60141-2-PBS. Standard:HZ-1318. Range: 0.049-3.125 ng/mL.

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  Sample test of MP50089-1

  Cytometric bead array of cell line supernatant using MP50089-1, CXCL8/IL-8 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 68744-1-PBS. Detection antibody: 60141-2-PBS. Supernatant (20μL/well) from the following cell lines were assayed: Caki-1, BT-549, Ramos.

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Informations sur le produit

60141-2-PBS cible CXCL8/IL-8 dans les applications de Sandwich ELISA, Indirect ELISA, Sample test et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: CXCL8/IL-8 Protéine recombinante Ag10552
• Nom complet: interleukin 8
• Masse moléculaire calculée: 99 aa, 11 kDa
• Numéro d’acquisition GenBank: BC013615
• Symbole du gène: IL-8
• Identification du gène (NCBI): 3576
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Interleukin 8 (IL-8), also known as CXCL8, which is a member of the CXC chemokine family. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. IL-8 has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also induces phagocytosis once they have arrived. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. IL-8 is also known to be a potent promoter of angiogenesis. IL-8 has been associated with tumor angiogenesis, metastasis, and poor prognosis in breast cancer. IL-8 may present a novel therapeutic target for estrogen driven breast carcinogenesis and tumor progression. The human IL-8 cDNA sequence predicts a protein of 99 amino acids. Removal of a 22-residue signal peptide generates a mature protein of 77 amino acids (~ 8 kDa).

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