Anticorps Recombinant de lapin anti-CXCR4/CD184

CXCR4/CD184 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

APC Fluorescent Dye

CloneNo.

241735F8

N° de cat : APC-98175

Synonymes

CXCR4, 241735F8, CD184, C-X-C chemokine receptor type 4, CXC R4

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Galerie de données de validation

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  FC experiment of human PBMCs using APC-98175

  1x10^6 human PBMCs were surface stained with 5 ul FITC Plus Anti-Human CD19 (4G7) Mouse IgG2a Recombinant Antibody (FITC-65562, Clone: 4G7), and 5 ul APC Anti-Human CXCR4/CD184 Rabbit RecAb (APC-98175, Clone: 241735F8) or APC Rabbit IgG Isotype Control RecAb (APC-98136, Clone: 240953C9). Cells were not fixed.

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  FC experiment of human PBMCs using APC-98175

  1x10^6 human PBMCs were surface stained with 5 ul APC Anti-Human CXCR4/CD184 Rabbit RecAb (APC-98175, Clone: 241735F8) or APC Rabbit IgG Isotype Control RecAb (APC-98136, Clone: 240953C9). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines,

Dilution recommandée

Application	Dilution
This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
Sample-dependent, check data in validation data gallery

Informations sur le produit

APC-98175 cible CXCR4/CD184 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: chemokine (C-X-C motif) receptor 4
• Masse moléculaire calculée: 352 aa, 40 kDa
• Numéro d’acquisition GenBank: BC020968
• Symbole du gène: CXCR4
• Identification du gène (NCBI): 7852
• Conjugaison: APC Fluorescent Dye
• Excitation/Emission maxima wavelengths: 650 nm / 660 nm
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide and 0.5% BSA
• Conditions de stockage: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

Informations générales

C-X-C chemokine receptor type 4 (CXCR4, also known as CD184) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609).

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