Anticorps Recombinant de lapin anti-CXXC5

CXXC5 Recombinant Antibody for IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241034E6

N° de cat : 83940-6-PBS

Synonymes

Putative MAPK-activating protein PM08, HSPC195, CXXC-type zinc finger protein 5, CXXC finger 5, CF5

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Galerie de données de validation

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  IF Staining of HepG2 using 83940-6-RR (same clone as 83940-6-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using CXXC5 antibody (83940-6-RR, Clone: 241034E6 ) at dilution of 1:250 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 83940-6-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 83940-6-RR

  Biolayer interferometry (BLl) kinetic assays of 83940-6-RR against Human CXXC5 were performed. The affinity constant is 6.36 nM.

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Informations sur le produit

83940-6-PBS cible CXXC5 dans les applications de IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: CXXC5 Protéine recombinante Ag9733
• Nom complet: CXXC finger 5
• Masse moléculaire calculée: 322aa,33 kDa; 227aa,24 kDa
• Numéro d’acquisition GenBank: BC017439
• Symbole du gène: CXXC5
• Identification du gène (NCBI): 51523
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CXXC5 (CXXC-type zinc finger protein 5) is also named as HSPC195, RINF and TCCCIA00297.CXXC5 is a member of the CXXC-type zinc-finger protein family. CXXC5 is a short protein (322 amino acids in length) that does not have any catalytic domain, but is able to bind to DNA and act as a transcription factor and epigenetic factor through protein-protein interactions. In addition, CXXC5 is capable of regulating various signal transduction processes, including the TGF-β, Wnt and ATM-p53 pathways, thereby acting as a novel and crucial signaling coordinator. CXXC5 plays an important role in embryonic development and adult tissue homeostasis by regulating cell proliferation, differentiation and apoptosis (PMID: 30479059). CXXC5 has two isoforms of 33 kDa and 24 kDa (PMID: 25805812). CXXC5 is modified by phosphorylation after translation.

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