Anticorps Polyclonal de lapin anti-CXorf21

CXorf21 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30244-1-PBS

Synonymes

TASL, TLR adapter interacting with SLC15A4 on the lysosome

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Galerie de données de validation

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  WB analysis using 30244-1-AP (same clone as 30244-1-PBS)

  THP-1 cells were subjected to SDS PAGE followed by western blot with 30244-1-AP (CXorf21 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of rat skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of rat skin using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat skin tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of rat stomach using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded rat stomach tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IHC staining of human cervical cancer using 30244-1-AP (same clone as 30244-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 30244-1-AP (CXorf21 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IF Staining of U2OS using 30244-1-AP (same clone as 30244-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed U2OS cells using CXorf21 antibody (30244-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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  IF Staining of U-251 using 30244-1-AP (same clone as 30244-1-PBS)

  Immunofluorescent analysis of (-20°C Ethanol) fixed U-251 cells using CXorf21 antibody (30244-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 30244-1-PBS in a different storage buffer formulation.

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Informations sur le produit

30244-1-PBS cible CXorf21 dans les applications de WB, IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CXorf21 Protéine recombinante Ag32773
• Nom complet: chromosome X open reading frame 21
• Poids moléculaire observé: 34 kDa
• Numéro d’acquisition GenBank: BC020611
• Symbole du gène: CXorf21
• Identification du gène (NCBI): 80231
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CXorf21 (Chromosome X open reading frame 21) is also named as TASL and TLR adapter interacting with SLC15A4 on the lysosome. CXorf21 is an innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PMID:32433612). CXorf21 plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PMID: 31001245). CXorf21 is a mediator of the X-chromosome gene dose-dependent increased risk of SLE in females (PMID: 31695690).

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