Anticorps Polyclonal de lapin anti-CYC1

• Phare
• Validé par KD/KO

CYC1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 10242-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of human brain using 10242-1-AP (same clone as 10242-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP (CYC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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  WB analysis of human brain using 10242-1-AP (same clone as 10242-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 10242-1-AP (CYC1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 10242-1-AP (CYC1 antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 10242-1-AP (CYC1 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 10242-1-AP (CYC1 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 10242-1-AP (same clone as 10242-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 10242-1-AP (CYC1 antibody) at dilution of 1:50 (under 25x lens). This data was developed using the same antibody clone with 10242-1-PBS in a different storage buffer formulation.

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Informations sur le produit

10242-1-PBS cible CYC1 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: CYC1 Protéine recombinante Ag0291
• Nom complet: cytochrome c-1
• Masse moléculaire calculée: 35 kDa
• Poids moléculaire observé: 35 kDa
• Numéro d’acquisition GenBank: BC001006
• Symbole du gène: CYC1
• Identification du gène (NCBI): 1537
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CYC1, also named as Cytochrome c-1, belongs to the cytochrome c family. Cytochrome c1 is one respiratory subunit of the 11 subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c(PMID:3036122 ). CYC1 mediates apoptosis. In this pathway, a variety of apoptotic stimuli cause CYC1 release from mitochondria, which in turn induces a series of biochemical reactions that result incaspase activation and subsequent cell death.(PMID:15189137) While CYC1 release and DNA fragmentation are unaffected by the noncleavablep75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed(PMID:15186778). The protein migrated as a 35 kd band in SDS page.

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