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Anticorps Polyclonal de lapin anti-Cadherin-11

Cadherin-11 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12028-1-PBS

Synonymes

CDH11, CAD11, Cadherin 11, CDHOB, OB

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of PC-3 cells using Cadherin-11 Polyclonal antibody (12028-1-AP)

    WB analysis of PC-3 using 12028-1-AP (same clone as 12028-1-PBS)

    PC-3 cells were subjected to SDS PAGE followed by western blot with 12028-1-AP (Cadherin-11 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12028-1-PBS in a different storage buffer formulation.

Informations sur le produit

12028-1-PBS cible Cadherin-11 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Cadherin-11 Protéine recombinante Ag2659
Nom complet cadherin 11, type 2, OB-cadherin (osteoblast)
Masse moléculaire calculée 796 aa, 88 kDa
Poids moléculaire observé120 kDa
Numéro d’acquisition GenBankBC013609
Symbole du gène CDH11
Identification du gène (NCBI) 1009
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Cadherin-11 (CDH11), also known osteoblast cadherin (OB-cadherin) or OSF-4, was identified initially in a mouse osteoblastic cell line and human osteosarcoma (PMID: 8163513). Cadherin-11 is a single pass transmembrane protein consisting of an extracellular domain which contains five repeat sequences (EC1-EC5), a transmembrane segment and a cytoplasmic domain which links catenins to the actin and microtubule cytoskeleton (PMID: 8163513; 33442417). It has been shown that cadherin-11 plays important roles in the occurrence and development of a lot of diseases, arthritis, cancer, aortic calcification disease, dermatosis (PMID: 33442417).

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