Anticorps Recombinant de lapin anti-Caspase 1

Caspase 1 Recombinant Antibody for IF-P, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IF-P, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241966A3

N° de cat : 84752-1-PBS

Synonymes

CASP1, Caspase1, Caspase-1, CASP-1, CASP 1

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Galerie de données de validation

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  IF Staining of mouse liver using 84752-1-RR (same clone as 84752-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse liver tissue using Caspase 1 antibody (84752-1-RR, Clone: 241966A3 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84752-1-PBS in a different storage buffer formulation.

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Informations sur le produit

84752-1-PBS cible Caspase 1 dans les applications de IF-P, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
• Masse moléculaire calculée: 404 aa, 45 kDa
• Numéro d’acquisition GenBank: BC062327
• Symbole du gène: Caspase 1
• Identification du gène (NCBI): 834
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products (PMID:21804020). It has 5 isoforms produced by alternative splicing.

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