Anticorps Recombinant de lapin anti-Cleaved Caspase 10/P23

Cleaved Caspase 10/P23 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242468G11

N° de cat : 85104-3-PBS

Synonymes

CASP10, Caspase10, 242468G11, Apoptotic protease Mch 4, Apoptotic protease Mch-4

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Galerie de données de validation

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  WB analysis of Jurkat using 85104-3-RR (same clone as 85104-3-PBS)

  Staurosporine treated Jurkat cells were subjected to SDS PAGE followed by western blot with 85104-3-RR (Cleaved Caspase 10/P23 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85104-3-PBS in a different storage buffer formulation.

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Informations sur le produit

85104-3-PBS cible Cleaved Caspase 10/P23 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: caspase 10, apoptosis-related cysteine peptidase
• Masse moléculaire calculée: 59 kDa
• Poids moléculaire observé: 23 kDa
• Numéro d’acquisition GenBank: BC042844
• Symbole du gène: Caspase 10
• Identification du gène (NCBI): 843
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

CASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). This antibody recognize the cleaved caspase 10.

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