Anticorps Monoclonal anti-Claudin 18

Claudin 18 Monoclonal Antibody for IHC, IP, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, souris

Applications

IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

5G7F2

N° de cat : 66167-1-PBS

Synonymes

UNQ778/PRO1572, CLDN18, Claudin-18, Claudin18, 5G7F2

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Galerie de données de validation

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  IP experiment of mouse stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  IP result of anti-Claudin 18 (IP:66167-1-Ig, 3ug; Detection:66167-1-Ig 1:300) with mouse stomach tissue lysate 4000ug. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:600 (under 10x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas cancer using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:600 (under 40x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary tumor using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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  IHC staining of human ovary tumor using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:1000. This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody) at dilution of 1:600 (under 40x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach using 66167-1-Ig (same clone as 66167-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66167-1-Ig (Claudin 18 antibody at dilution of 1:600 (under 10x lens). This data was developed using the same antibody clone with 66167-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66167-1-PBS cible Claudin 18 dans les applications de IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Claudin 18 Protéine recombinante Ag15517
• Nom complet: claudin 18
• Masse moléculaire calculée: 261 aa, 28 kDa
• Poids moléculaire observé: 29 kDa
• Numéro d’acquisition GenBank: BC146668
• Symbole du gène: CLDN18
• Identification du gène (NCBI): 51208
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145). This antibody can recognize both CLDN18.1 and CLDN18.2.

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