Anticorps Polyclonal de lapin anti-Cubilin

Cubilin Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31992-1-PBS

Synonymes

Intrinsic factor-vitamin B12 receptor, Intrinsic factor-cobalamin receptor, Intestinal intrinsic factor receptor, IFCR, CUBN

---

Galerie de données de validation

• 

  WB analysis using 31992-1-AP (same clone as 31992-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31992-1-AP (CUBN antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31992-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

31992-1-PBS cible Cubilin dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Cubilin Protéine recombinante Ag35808
• Nom complet: cubilin (intrinsic factor-cobalamin receptor)
• Masse moléculaire calculée: 398kDa
• Poids moléculaire observé: 450 kDa
• Numéro d’acquisition GenBank: NM_001081
• Symbole du gène: CUBN
• Identification du gène (NCBI): 8029
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. Cubilin is an endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PMID: 9572993). Cubilin Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1, which also acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PMID: 14576052). There are multiple glycosylation sites on Cubilin.

{{ptg:RelatedPrimaryAntibodies}}