Anticorps Recombinant de lapin anti-DC-SIGNR/CD299

DC-SIGNR/CD299 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241683G8

N° de cat : 98205-1-PBS

Synonymes

CLEC4M, CD299, CD209L1, CD209L, CD209 antigen-like protein 1

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98205-1-RR (same clone as 98205-1-PBS)

  1x10^6 HEK-293T cells or DC-SIGNR/CD299 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human DC-SIGNR/CD299 Rabbit Recombinant Antibody (98205-1-RR, Clone: 241683G8) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98205-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98205-1-RR (same clone as 98205-1-PBS)

  1x10^6 HEK-293T cells or DC-SIGNR/CD299 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human DC-SIGNR/CD299 Rabbit Recombinant Antibody (98205-1-RR, Clone:241683G8) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98205-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98205-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98205-1-RR against Human DC-SIGNR/CD299 were performed. The affinity constant is 3.68 nM.

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Informations sur le produit

98205-1-PBS cible DC-SIGNR/CD299 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: C-type lectin domain family 4, member M
• Masse moléculaire calculée: 45 kDa
• Numéro d’acquisition GenBank: BC038851
• Symbole du gène: DC-SIGNR/CD299
• Identification du gène (NCBI): 10332
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin (DC-SIGN/CD209) and DC-SIGN related (DC-SIGNR/CD299/L-SIGN/CD209L/CLEC4M) are trans-membrane C-type lectins that are calcium-dependent carbohydrate-binding proteins, which can act as cell-adhesion and pathogen-recognition receptors (PMID: 18458800). DC-SIGN and DC-SIGNR share 77% amino acid identity (PMID: 10975799; 11226297). DC-SIGN is expressed on subsets of dendritic cells and macrophages while DC-SIGNR is restricted to endothelial cells of the liver, lymph nodes and placenta (PMID: 17509452). DC-SIGNR servers as a receptor for ICAM-3. It recognizes a wide range of evolutionarily divergent pathogens.

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