Anticorps Polyclonal de lapin anti-DCC-Specific

DCC-Specific Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 19123-1-PBS

Synonymes

DCC, Colorectal cancer suppressor, CRC18, CRCR1, IGDCC1

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Galerie de données de validation

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  WB analysis of mouse brain using 19123-1-AP (same clone as 19123-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 19123-1-AP (DCC-Specific Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19123-1-PBS in a different storage buffer formulation.

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  WB analysis of A-673 using 19123-1-AP (same clone as 19123-1-PBS)

  A-673 cells were subjected to SDS PAGE followed by western blot with 19123-1-AP (DCC-Specific antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19123-1-PBS in a different storage buffer formulation.

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Informations sur le produit

19123-1-PBS cible DCC-Specific dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: deleted in colorectal carcinoma
• Masse moléculaire calculée: 1447 aa, 158 kDa
• Poids moléculaire observé: 180 kDa
• Numéro d’acquisition GenBank: NM_005215
• Symbole du gène: DCC
• Identification du gène (NCBI): 1630
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene. This antibody raised against a synthesized polypeptide of human DCC protein recognizes endogenous DCC with an apparent molecular weight of 180 kDa. As the predicted molecular mass of DCC is 158 kDa, the slower mobility is likely attributable to post-translational modification, perhaps by glycosylation at potential N-linked glycosylation sites (PMID: 7926722; 8044801).

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