Anticorps Recombinant de lapin anti-DDR1/CD167a

DDR1/CD167a Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241796D10

N° de cat : 84438-6-PBS

Synonymes

DDR1, 241796D10, CAK, CD167, CD167 antigen-like family member A

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Galerie de données de validation

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  WB analysis using 84438-6-RR (same clone as 84438-6-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84438-6-RR (DDR1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84438-6-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 84438-6-RR (same clone as 84438-6-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 84438-6-RR (DDR1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84438-6-PBS in a different storage buffer formulation.

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Informations sur le produit

84438-6-PBS cible DDR1/CD167a dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: DDR1/CD167a Protéine recombinante Eg1675
• Nom complet: discoidin domain receptor tyrosine kinase 1
• Masse moléculaire calculée: 101 kDa
• Poids moléculaire observé: 120 kDa
• Numéro d’acquisition GenBank: NM_001297654
• Symbole du gène: DDR1
• Identification du gène (NCBI): 780
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DDR1, or Discoidin Domain Receptor 1, is a member of the receptor tyrosine kinase (RTK) family, which plays a significant role in various cellular processes including cell proliferation, adhesion, migration, and extracellular matrix (ECM) remodeling. DDR1 is known for its unique discoidin domain that allows it to bind specifically to certain collagens, initiating downstream signaling pathways that can lead to cell transformation and tumor progression. Abnormal activation of DDR1 is closely associated with the development of various solid tumors, and it has been shown that DDR1 can prevent immune cells from infiltrating triple-negative breast cancer (TNBC) and eliminate tumor cells.

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