Anticorps Monoclonal anti-DDR2

DDR2 Monoclonal Antibody for WB, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(2)

CloneNo.

1E9A10

N° de cat : 67126-1-Ig

Synonymes

DDR2, Discoidin domain receptor 2, MIG20a, NTRKR3, TKT, TYRO10, Tyrosine protein kinase TYRO10

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Galerie de données de validation

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  WB analysis of Jurkat using 67126-1-Ig

  Jurkat cells were subjected to SDS PAGE followed by western blot with 67126-1-Ig (DDR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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  WB analysis of HEK-293 using 67126-1-Ig

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 67126-1-Ig (DDR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of HepG2 using 67126-1-Ig

  HepG2 cells were subjected to SDS PAGE followed by western blot with 67126-1-Ig (DDR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

• 

  WB analysis of HeLa using 67126-1-Ig

  HeLa cells were subjected to SDS PAGE followed by western blot with 67126-1-Ig (DDR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules Jurkat, cellules HEK-293, cellules HeLa, cellules HepG2

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below
• IF: See 1 publications below

Informations sur le produit

67126-1-Ig cible DDR2 dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: DDR2 Protéine recombinante Ag28340
• Nom complet: discoidin domain receptor tyrosine kinase 2
• Masse moléculaire calculée: 97 kDa
• Poids moléculaire observé: 100-110 kDa
• Numéro d’acquisition GenBank: NM_001014796
• Symbole du gène: DDR2
• Identification du gène (NCBI): 4921
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

DDR2 (Discoidin domain receptor 2) belongs to the receptor tyrosine kinase (RTK) family and is activated by collagen-binding.DDR2 is implicated in several physiological and pathological processes, including wound healing, angiogenesis, ovulation, spermatogenesis, extracellular matrix (ECM) remodeling and fibrosis, and tumor progression (PMID: 25805889). Moreover, DDR2 is prominently present in the fibroblasts, smooth muscle cells, myofibroblasts, and chondrocytes (PMID: 37834343).

Publications

Species	Application	Title
human	IF	J Cell Mol Med; The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.; Authors - Ke Xue
human	WB	Int J Biol Macromol; Human type III collagen-derived biomaterial with high antitumor activity inhibits breast cancer cell autophagy, proliferation, and migration through DDR1; Authors - Xiaowei Liu

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