Anticorps Polyclonal de lapin anti-DEFB119

DEFB119 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33236-1-PBS

Synonymes

Beta-defensin 119, Beta-defensin 120, Beta-defensin 19, Beta-defensin 20, DEFB120

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Galerie de données de validation

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  WB analysis using 33236-1-AP (same clone as 33236-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33236-1-AP (DEFB119 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33236-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33236-1-PBS cible DEFB119 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DEFB119 Protéine recombinante Ag36816
• Nom complet: defensin, beta 119
• Masse moléculaire calculée: 84 aa, 10 kDa
• Poids moléculaire observé: 10 kDa
• Numéro d’acquisition GenBank: BC062212
• Symbole du gène: DEFB119
• Identification du gène (NCBI): 245932
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DEFB119 is a reproductive tract-specific β-defensin highly expressed in the testis and the epididymis (16). Single-cell sequencing analysis of testicular cells isolated from nonobstructive azoospermia men demonstrates an elevated expression of DEFB119 in the Sertoli cells. Male mice lacking the mouse ortholog DEFB19 demonstrated subfertility in both sexes. DEFB119 is also expressed in sperm and is involved in sperm chemotaxis. Elevated seminal DEFB119 was associated with a decrease in the observed genera, diversity and evenness of bacterial communities, and further distortion of the metacommunities (PMID: 39359400).

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