Anticorps Polyclonal de lapin anti-DHX37

• Phare
• Validé par KD/KO

DHX37 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(1)

N° de cat : 29741-1-AP

Synonymes

DDX37, DEAH box protein 37, DHX37, FLJ41974, KIAA1517

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Galerie de données de validation

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  WB analysis using 29741-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 29741-1-AP (DHX37 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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  WB analysis of HEK-293 using 29741-1-AP

  WB result of DHX37 antibody (29741-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-DHX37 transfected HEK-293 cells.

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Applications testées

• Résultats positifs en WB: cellules HEK-293, cellules HeLa, cellules HepG2

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 1 publications below

Informations sur le produit

29741-1-AP cible DHX37 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DHX37 Protéine recombinante Ag29909
• Nom complet: DEAH (Asp-Glu-Ala-His) box polypeptide 37
• Masse moléculaire calculée: 1157 aa, 130 kDa
• Poids moléculaire observé: 130 kDa
• Numéro d’acquisition GenBank: BC037964
• Symbole du gène: DHX37
• Identification du gène (NCBI): 57647
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

DHX37, also known as DDX37, KIAA1517. It is an ATP-bound RNA helicase that plays a role in the maturation of small ribosomal subunits in ribosomal biogenesis (PMID:30582406). The presence of DHX37 in early pre-ribosomal particles was monitored by a quality control pathway, and failure to recruit DHX37 resulted in pre-RRNA degradation. DHX37 binds directly to U3 small nucleolar RNA (snoRNA), and the catalytic activity of the helicase is required for dissociation of U3 small nucleolar RNA from the pre-ribosomal complex.In addition, it plays a role in early testicular development (PMID:31287541, PMID:31337883). It may also have an effect on brain development (PubMed:31256877). It is expressed in the fallopian tubes, ovaries, uterus, testes and brain (PMID: 31256877,PMID: 31337883).

Publications

Species	Application	Title
human	WB	Cancers (Basel); DHX37 Is a Promising Prognostic Biomarker and a Therapeutic Target for Immunotherapy and Chemotherapy in HCC; Authors - Nanbin Liu

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