Anticorps Polyclonal de lapin anti-DHX37

• Phare
• Validé par KD/KO

DHX37 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29741-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 29741-1-AP (same clone as 29741-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29741-1-AP (DHX37 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29741-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 29741-1-AP (same clone as 29741-1-PBS)

  WB result of DHX37 antibody (29741-1-AP; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-DHX37 transfected HEK-293 cells. This data was developed using the same antibody clone with 29741-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29741-1-PBS cible DHX37 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DHX37 Protéine recombinante Ag29909
• Nom complet: DEAH (Asp-Glu-Ala-His) box polypeptide 37
• Masse moléculaire calculée: 1157 aa, 130 kDa
• Poids moléculaire observé: 130 kDa
• Numéro d’acquisition GenBank: BC037964
• Symbole du gène: DHX37
• Identification du gène (NCBI): 57647
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DHX37, also known as DDX37, KIAA1517. It is an ATP-bound RNA helicase that plays a role in the maturation of small ribosomal subunits in ribosomal biogenesis (PMID:30582406). The presence of DHX37 in early pre-ribosomal particles was monitored by a quality control pathway, and failure to recruit DHX37 resulted in pre-RRNA degradation. DHX37 binds directly to U3 small nucleolar RNA (snoRNA), and the catalytic activity of the helicase is required for dissociation of U3 small nucleolar RNA from the pre-ribosomal complex.In addition, it plays a role in early testicular development (PMID:31287541, PMID:31337883). It may also have an effect on brain development (PubMed:31256877). It is expressed in the fallopian tubes, ovaries, uterus, testes and brain (PMID: 31256877,PMID: 31337883).

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