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Anticorps Monoclonal anti-DHX37

DHX37 Monoclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2B12D9

N° de cat : 67853-1-PBS

Synonymes

DDX37, DEAH box protein 37, DHX37, FLJ41974, KIAA1517

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using DHX37 Monoclonal antibody (67853-1-Ig)

    WB analysis using 67853-1-Ig (same clone as 67853-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67853-1-Ig (DHX37 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67853-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using DHX37 Monoclonal antibody (67853-1-Ig)

    IF Staining of HeLa using 67853-1-Ig (same clone as 67853-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using DHX37 antibody (67853-1-Ig, Clone: 2B12D9 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 67853-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using DHX37 Monoclonal antibody (67853-1-Ig)

    IF Staining of HeLa using 67853-1-Ig (same clone as 67853-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using DHX37 antibody (67853-1-Ig, Clone: 2B12D9 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 67853-1-PBS in a different storage buffer formulation.

Informations sur le produit

67853-1-PBS cible DHX37 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Mouse / IgG2a
Clonalité Monoclonal
Type Anticorps
Immunogène DHX37 Protéine recombinante Ag29909
Nom complet DEAH (Asp-Glu-Ala-His) box polypeptide 37
Masse moléculaire calculée 1157 aa, 130 kDa
Poids moléculaire observé130-140 kDa
Numéro d’acquisition GenBankBC037964
Symbole du gène DHX37
Identification du gène (NCBI) 57647
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DHX37, also known as DDX37, KIAA1517. It is an ATP-bound RNA helicase that plays a role in the maturation of small ribosomal subunits in ribosomal biogenesis (PMID:30582406). The presence of DHX37 in early pre-ribosomal particles was monitored by a quality control pathway, and failure to recruit DHX37 resulted in pre-RRNA degradation. DHX37 binds directly to U3 small nucleolar RNA (snoRNA), and the catalytic activity of the helicase is required for dissociation of U3 small nucleolar RNA from the pre-ribosomal complex.In addition, it plays a role in early testicular development (PMID:31287541, PMID:31337883). It may also have an effect on brain development (PubMed:31256877). It is expressed in the fallopian tubes, ovaries, uterus, testes and brain (PMID: 31256877,PMID: 31337883).

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