Anticorps Recombinant de lapin anti-DOPA decarboxylase/DDC

DOPA decarboxylase/DDC Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243125A1

N° de cat : 85811-2-PBS

Synonymes

DDC, DOPA decarboxylase, AADC, Aromatic-L-amino-acid decarboxylase, EC:4.1.1.28

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Galerie de données de validation

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  WB analysis using 85811-2-RR (same clone as 85811-2-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85811-2-RR (DOPA decarboxylase/DDC antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85811-2-PBS in a different storage buffer formulation.

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Informations sur le produit

85811-2-PBS cible DOPA decarboxylase/DDC dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: DOPA decarboxylase/DDC Protéine recombinante Ag0219
• Nom complet: dopa decarboxylase (aromatic L-amino acid decarboxylase)
• Masse moléculaire calculée: 54 kDa
• Poids moléculaire observé: 48-50 kDa
• Numéro d’acquisition GenBank: BC008366
• Symbole du gène: DOPA decarboxylase
• Identification du gène (NCBI): 1644
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DOPA decarboxylase (DDC), also known as aromatic l-amino acid decarboxylase, belongs to the pyridoxal-dependent aminotransferase superfamily. DDC is an enzyme that converts levodopa into dopamine14, the latter being severely depleted in LBD due to the loss of dopaminergic neurons in the substantia nigra (PMID: 3374198, PMID: 28100251). DDC catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. DDC is the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). Researches showed that Ddc is only one of the enzymes in the biosynthetic pathways for bioamines and catecholamines.

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