Anticorps Recombinant de lapin anti-DR4

DR4 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250737E11

N° de cat : 98511-1-PBS

Synonymes

APO2, CD261, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A

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Galerie de données de validation

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  FC experiment of HEL92.1.7 using 98511-1-RR (same clone as 98511-1-PBS)

  1x10^6 HEL92.1.7 (left) or 1x10^6 PBMC cells (right) were surface stained with 0.15 ug Anti-Human DR4 Rabbit RecAb (98511-1-RR, Clone: 250737E11) (red) or 0.15 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98511-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98511-1-PBS cible DR4 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: DR4 Protéine recombinante Eg4600
• Nom complet: tumor necrosis factor receptor superfamily, member 10a
• Masse moléculaire calculée: 50 kDa
• Numéro d’acquisition GenBank: BC012866
• Symbole du gène: DR4
• Identification du gène (NCBI): 8797
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL activates apoptosis through the death receptors DR4 (also known as TRAILR1 and TNFRSF10A) and DR5 (also known as TRAILR2, KILLER and TNFRSF10B). DR4 and DR5 are single-pass type I membrane proteins that contain intracellular death domains (DD) and upon activation mediate apoptotic signals (PMID: 11163110). Binding of TRAIL to DR4 or DR5 results in receptor oligomerization and recruitment of FAS-associated protein with death domain (FADD) and caspase 8 to form a functional death-inducing signalling complex (DISC). Upon DISC formation, caspase 8 is cleaved and activated, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PMID: 18813321). DR4 or DR5 promotes the activation of NF-kappa-B and play an important role in inflammation (PMID: 9430227, 19434100).

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