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Anticorps Recombinant de lapin anti-DR5

DR5 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241847B8

N° de cat : 84524-4-PBS

Synonymes

Tnfrsf10b, MK, Killer, Death receptor 5, CD262

Galerie de données de validation

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  • Western Blot (WB) analysis of NIH/3T3 cells using DR5 Recombinant antibody (84524-4-RR)

    WB analysis of NIH/3T3 using 84524-4-RR (same clone as 84524-4-PBS)

    NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 84524-4-RR (DR5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84524-4-PBS in a different storage buffer formulation.

Informations sur le produit

84524-4-PBS cible DR5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons souris

Réactivité souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène FusionProtein
Nom complet tumor necrosis factor receptor superfamily, member 10b
Masse moléculaire calculée42kDa
Poids moléculaire observé50 kDa
Numéro d’acquisition GenBankNM_020275.4
Symbole du gène DR5
Identification du gène (NCBI) 21933
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DR5, also known as CD262, TNFRSF10B, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells (PMID: 9311998). DR5 contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which DR5 is capable to transmit the apoptotic signal (PMID: 9311998; 20531300).

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