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Anticorps Polyclonal de lapin anti-DR5-Specific

DR5-Specific Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15497-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of PC-3 cells using DR5-Specific Polyclonal antibody (15497-1-AP)

    WB analysis of PC-3 cells using 15497-1-AP (same clone as 15497-1-PBS)

    WB result of 15497-1-AP (TNFRSF10B, DR5 antibody) with PC-3 cell, untreated or treated with tunicamysin. This data was developed using the same antibody clone with 15497-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HL-60 cells using DR5-Specific Polyclonal antibody (15497-1-AP)

    WB analysis of HL-60 using 15497-1-AP (same clone as 15497-1-PBS)

    HL-60 cells were subjected to SDS PAGE followed by western blot with 15497-1-AP (TNFRSF10B-Specific antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15497-1-PBS in a different storage buffer formulation.

Informations sur le produit

15497-1-PBS cible DR5-Specific dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Peptide
Nom complet tumor necrosis factor receptor superfamily, member 10b
Masse moléculaire calculée 48 kDa
Poids moléculaire observé 58-60 kDa, 45-50 kDa, 32 kDa
Numéro d’acquisition GenBankNM_003842
Symbole du gène DR5
Identification du gène (NCBI) 8795
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TNFRSF10B, also known as CD262, DR5, TRAILR2, TRICK2 and KILLER, is a widely expressed single-pass type I membrane protein belonging to the tumour necrosis factor receptor superfamily (TNFRSF). It is a receptor for TNF-related apoptosis-inducing ligand (TRAIL), which is a member of the tumor necrosis factor (TNF) family of cytokines and induces apoptosis in a wide variety of cells (PMID: 9311998). TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain (DD), through which TNFRSF10B is capable to transmit the apoptotic signal (PMID: 9311998; 20531300). In PDAC cells, especially Panc89 cells, it expresses additionally to the approximately 48 and 40 kDa forms of DR5, a faster migrating variant of DR5 of about 32 kDa(PMID:20354842). The TRAIL receptor 2 (death receptor 5, or DR5) forms receptor dimers in a ligand-dependent manner, and these receptor dimers exist within high molecular weight networks(Dr. Jonathan N. Sachs,2012).

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