Anticorps Polyclonal de lapin anti-DRAM

DRAM Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31777-1-PBS

Synonymes

DRAM1, DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator

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Galerie de données de validation

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  WB analysis using 31777-1-AP (same clone as 31777-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31777-1-AP (DRAM antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31777-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31777-1-PBS cible DRAM dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DRAM Protéine recombinante Ag33711
• Nom complet: damage-regulated autophagy modulator
• Masse moléculaire calculée: 26 kDa
• Poids moléculaire observé: 33 kDa
• Numéro d’acquisition GenBank: BC018435
• Symbole du gène: DRAM
• Identification du gène (NCBI): 55332
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Damage-regulated autophagy modulator (DRAM) is a lysosomal membrane protein of autophagy that enriches in lung tissue and plays a central role in p53/TP53-mediated apoptosis (PMID: 16839881), which increased autophagy flux by promoting lysosomal acidification and protease activation (PMID: 23696801). It has 238 amino acids and six hydrophobic transmembrane regions. Reports show DRAM to be downregulated in squamous cancers, indicating a selective pressure to lose DRAM during tumor development (PMID: 17102582). Overexpression of DRAM1 can promote mitophagy and enhance mitochondrial function (PMID: 31204316).

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