Anticorps Monoclonal anti-Desmocollin 2

Desmocollin 2 Monoclonal Antibody for FC, WB, ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, souris

Applications

WB, IF, FC, ELISA

Conjugaison

Non conjugué

CloneNo.

1H8G1

N° de cat : 60239-1-Ig

Synonymes

ARVD11, Cadherin family member 2, CDHF2, desmocollin 2, Desmocollin 3, Desmosomal glycoprotein II, Desmosomal glycoprotein III, DG2, DGII/III, DSC2, DSC3



Applications testées

Résultats positifs en WBcellules HEK-293, cellules Raji
Résultats positifs en cytométriecellules HEK-293,

Dilution recommandée

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
Flow Cytometry (FC)FC : 1:10-1:100
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

60239-1-Ig cible Desmocollin 2 dans les applications de WB, IF, FC, ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Réactivité citéeHumain
Hôte / Isotype Mouse / IgG2a
Clonalité Monoclonal
Type Anticorps
Immunogène Desmocollin 2 Protéine recombinante Ag5450
Nom complet desmocollin 2
Masse moléculaire calculée 100 kDa
Poids moléculaire observé 110 kDa
Numéro d’acquisition GenBankBC063291
Symbole du gène DSC2
Identification du gène (NCBI) 1824
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
Conditions de stockageStocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Desmocollin 2 (DSC2) is a member of the desmocollin subfamily of the cadherin superfamily. The desmocollins (DSC1-3), along with the desmogleins (DSG1-4), are found primarily in epithelia and cardiac muscle where they constitute the adhesive proteins of the intercellular desmosome junctions and are required for cell adhesion and desmosome formation. Mutations in DSC2 gene are associated with arrhythmogenic right ventricular dysplasia-11.

Protocole

Product Specific Protocols
WB protocol for Desmocollin 2 antibody 60239-1-IgDownload protocol
FC protocol for Desmocollin 2 antibody 60239-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Acta Physiol (Oxf)

Clustering of desmosomal cadherins by desmoplakin is essential for cell-cell adhesion.

Authors - Marie-Therès Wanuske
humanWB

PLoS Pathog

Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1.

Authors - Hiroki Takeuchi
humanIF

Stem Cell Res Ther

Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth.

Authors - Ling Leng
humanWB

Mol Ther Oncolytics

Exosomal miR-205-5p enhances angiogenesis and nasopharyngeal carcinoma metastasis by targeting desmocollin-2.

Authors - Wenjuan Yang

Avis

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


FH

Jane (Verified Customer) (02-03-2022)

A very weak and smear band found around the right molecular weight. However, the quality is not good enough to do any analysis or generate results.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:200
  • Cell Tissue Type: Cardiomyoyctes
FH

Jing (Verified Customer) (02-04-2020)

Tested in hiPSC-derived cardiomyocytes, it showed band around 130Kd.

  • Applications: Western Blot,
  • Primary Antibody Dilution: 1:1000
  • Cell Tissue Type: hiPSC-derived cardiomyocytes