Anticorps Monoclonal anti-DSG2

DSG2 Monoclonal Antibody for WB, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1B8C3

N° de cat : 68515-1-PBS

Synonymes

ARVC10, ARVD10, Cadherin family member 5, CDHF5, Desmoglein 2

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Galerie de données de validation

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  WB analysis using 68515-1-Ig (same clone as 68515-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68515-1-Ig (DSG2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68515-1-PBS in a different storage buffer formulation.

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  WB analysis of K-562 using 68515-1-Ig (same clone as 68515-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 68515-1-Ig (DSG2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68515-1-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP51241-1

  Cytometric bead array standard curve of MP51241-1, DSG2 Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 68515-1-PBS. Detection antibody: 68515-2-PBS. Standard:Ag20633. Range: 0.391-100 ng/mL.

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Informations sur le produit

68515-1-PBS cible DSG2 dans les applications de WB, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: DSG2 Protéine recombinante Ag20633
• Nom complet: desmoglein 2
• Masse moléculaire calculée: 1118 aa, 122 kDa
• Poids moléculaire observé: 145-150 kDa
• Numéro d’acquisition GenBank: BC099655
• Symbole du gène: DSG2
• Identification du gène (NCBI): 1829
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmosomal cadherins, consisting of four desmogleins (DSG1-4) and three desmocollins (DSC1-3) in humans, mediate adhesion through calcium-dependent homophilic/heterophilic interactions. DSG2 is a single-pass transmembrane glycoprotein that is widely expressed in epithelial and non-epithelial tissues, such as the intestine, epidermis, testis, and heart (PMID:21715983). Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10), and genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB).

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