Anticorps Polyclonal de lapin anti-DUSP10

DUSP10 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30493-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 30493-1-AP (same clone as 30493-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30493-1-AP (DUSP10 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30493-1-PBS in a different storage buffer formulation.

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Informations sur le produit

30493-1-PBS cible DUSP10 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DUSP10 Protéine recombinante Ag32718
• Nom complet: dual specificity phosphatase 10
• Poids moléculaire observé: 53 kDa
• Numéro d’acquisition GenBank: BC031405
• Symbole du gène: DUSP10
• Identification du gène (NCBI): 11221
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DUSP10, also known as MKP5, is a member of the MKPs subfamily involved in cell proliferation, differentiation, and migration. DUSP10 is a dual specificity phosphatase capable of dephosphorylating both pTyr and pThr residues of activated MAPKs with different affinities. It has been shown that isoforms of the p38 and JNK subfamilies are selectively and more effectively dephosphorylated than ERK subfamily members. DUSP10 has been proposed as a target for therapeutic treatment of atherosclerosis, since DUSP10 inhibition reduces NF-κB-induced TNF-α expression and increases TGF-β1 levels in this disease (PMID: 30939861).

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