Anticorps Polyclonal de lapin anti-DUSP6

DUSP6 Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

Publications

5

N° de cat : 10433-1-AP

Synonymes

dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1

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Galerie de données de validation

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Applications testées

Dilution recommandée

Application	Dilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 4 publications below
• IHC: See 1 publications below

Informations sur le produit

10433-1-AP cible DUSP6 dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DUSP6 Protéine recombinante Ag0705
• Nom complet: dual specificity phosphatase 6
• Masse moléculaire calculée: 42 kDa
• Numéro d’acquisition GenBank: BC003562
• Symbole du gène: DUSP6
• Identification du gène (NCBI): 1848
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS avec azoture de sodium à 0,02 % et glycérol à 50 % pH 7,3
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).

Publications

Species	Application	Title
human	WB	Br J Pharmacol; L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.; Authors - Yi-Ping Leng
mouse	WB	Ren Fail; LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis; Authors - Taoxia Wang
mouse	WB	Mol Cell Biochem; PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.; Authors - Jeong Hyo-Soon HS
human	IHC	Chin Med J (Engl); Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma.; Authors - Bo Yang
rat	WB	Biochim Biophys Acta; VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.; Authors - Kang Tae-Hong TH