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Anticorps Polyclonal de lapin anti-DYRK1A

DYRK1A Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28607-1-PBS

Synonymes

DYRK, DYRK1, hMNB, HP86, MNB

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using DYRK1A Polyclonal antibody (28607-1-AP)

    WB analysis using 28607-1-AP (same clone as 28607-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28607-1-AP (DYRK1A antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28607-1-PBS in a different storage buffer formulation.

Informations sur le produit

28607-1-PBS cible DYRK1A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène DYRK1A Protéine recombinante Ag29433
Nom complet dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Masse moléculaire calculée 86 kDa
Poids moléculaire observé70kDa, 85 kDa
Numéro d’acquisition GenBankNM_001396
Symbole du gène DYRK1A
Identification du gène (NCBI) 1859
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome.

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