Anticorps Polyclonal de lapin anti-DYRK2

DYRK2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 21979-1-PBS

Synonymes

Dual specificity tyrosine-phosphorylation-regulated kinase 2, DYRK 2, EC:2.7.12.1

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Galerie de données de validation

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  WB analysis using 21979-1-AP (same clone as 21979-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21979-1-AP (DYRK2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21979-1-PBS in a different storage buffer formulation.

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  IF Staining of K-562 using 21979-1-AP (same clone as 21979-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed K-562 cells using DYRK2 antibody (21979-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 21979-1-PBS in a different storage buffer formulation.

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Informations sur le produit

21979-1-PBS cible DYRK2 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DYRK2 Protéine recombinante Ag13480
• Nom complet: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
• Masse moléculaire calculée: 67 kDa
• Poids moléculaire observé: 67~70 kDa
• Numéro d’acquisition GenBank: BC006375
• Symbole du gène: DYRK2
• Identification du gène (NCBI): 8445
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

DYRK (Dual-specificity tyrosine phosphorylation-regulated kinase 2) is the only member of the Dual-specificity tYrosine phosphorylation-Regulated Kinase (DYRK) family that functions as a kinase activity-independent scaffold for an E3 ubiquitin ligase complex (PMID: 33376136). DYRK2 is involved in cell survival, development, differentiation, gene transcription, proteasomal regulation, and microtubule formation. DYRK2 is a key regulator of cell cycle and apoptosis in response to DNA damage via phosphorylation of p53. DYRK2 has two isoforms and is mostly localized in the cytoplasm; however, it accumulates in the nucleus under genotoxic stress conditions (PMID: 31505048, 37886981).

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