Anticorps Polyclonal de lapin anti-DcR2

DcR2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16781-1-PBS

Synonymes

CD264, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D, TRAIL R4

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Galerie de données de validation

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  WB analysis using 16781-1-AP (same clone as 16781-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16781-1-AP (DcR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16781-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16781-1-AP (same clone as 16781-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney using 16781-1-AP (DcR2 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16781-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 16781-1-AP (same clone as 16781-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney using 16781-1-AP (DcR2 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16781-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16781-1-PBS cible DcR2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: DcR2 Protéine recombinante Ag10208
• Nom complet: tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
• Masse moléculaire calculée: 386 aa, 42 kDa
• Poids moléculaire observé: 50-55 kDa
• Numéro d’acquisition GenBank: BC052270
• Symbole du gène: DcR2
• Identification du gène (NCBI): 8793
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Decoy receptor 2 (DcR2) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It functions as a decoy receptor for TNF-related apoptosis-inducing ligand (TRAIL), thereby inhibiting TRAIL-mediated apoptosis (PMID: 15538968; 9537512). It has been considered a tentative marker of cellular senescence (PMID: 16079833; 22751116). Additionally, DCR2 has been implicated in the regulation of renal fibrosis and cell senescence, contributing to the pathogenesis of diabetic nephropathy (PMID: 35661704).

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