Anticorps Monoclonal anti-Desmocollin 2

Desmocollin 2 Monoclonal Antibody for WB, IF-P, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, rat, souris

Applications

WB, IF-P, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1H8G1

N° de cat : 60239-1-PBS

Synonymes

DSC2, 1H8G1, ARVD11, Cadherin family member 2, CDHF2

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Galerie de données de validation

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  WB analysis of HEK-293 using 60239-1-Ig (same clone as 60239-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 60239-1-Ig (Desmocollin 2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60239-1-PBS in a different storage buffer formulation.

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  WB analysis of Raji using 60239-1-Ig (same clone as 60239-1-PBS)

  Raji cells were subjected to SDS PAGE followed by western blot with 60239-1-Ig (Desmocollin 2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60239-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293 using 60239-1-Ig (same clone as 60239-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 60239-1-Ig (Desmocollin 2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60239-1-PBS in a different storage buffer formulation.

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  IF Staining of mouse heart using 60239-1-Ig (same clone as 60239-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse heart tissue using Desmocollin 2 antibody (60239-1-Ig, Clone: 1H8G1 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60239-1-PBS in a different storage buffer formulation.

• 

  IF Staining of rat heart using 60239-1-Ig (same clone as 60239-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded rat heart tissue using Desmocollin 2 antibody (60239-1-Ig, Clone: 1H8G1 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60239-1-PBS in a different storage buffer formulation.

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Informations sur le produit

60239-1-PBS cible Desmocollin 2 dans les applications de WB, IF-P, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Desmocollin 2 Protéine recombinante Ag5450
• Nom complet: desmocollin 2
• Masse moléculaire calculée: 100 kDa
• Poids moléculaire observé: 110 kDa
• Numéro d’acquisition GenBank: BC063291
• Symbole du gène: Desmocollin 2
• Identification du gène (NCBI): 1824
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Desmocollin 2 (DSC2) is a member of the desmocollin subfamily of the cadherin superfamily. The desmocollins (DSC1-3), along with the desmogleins (DSG1-4), are found primarily in epithelia and cardiac muscle where they constitute the adhesive proteins of the intercellular desmosome junctions and are required for cell adhesion and desmosome formation. Mutations in DSC2 gene are associated with arrhythmogenic right ventricular dysplasia-11.

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