Anticorps Recombinant de lapin anti-Draxin

Draxin Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250677C12

N° de cat : 86244-1-PBS

Synonymes

C1orf187, AGPA3119, Dorsal inhibitory axon guidance protein, Neucrin, PSEC0258

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Galerie de données de validation

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  WB analysis using 86244-1-RR (same clone as 86244-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86244-1-RR (Draxin antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86244-1-PBS in a different storage buffer formulation.

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Informations sur le produit

86244-1-PBS cible Draxin dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Draxin Protéine recombinante Eg4203
• Nom complet: chromosome 1 open reading frame 187
• Masse moléculaire calculée: 39 kDa
• Poids moléculaire observé: 42 kDa
• Numéro d’acquisition GenBank: NM_198545.3
• Symbole du gène: C1orf187
• Identification du gène (NCBI): 374946
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Draxin(Dorsal repulsive axon guidance protein) is a repulsive axon guidance cue. It is widely expressed in the developing hippocampus, glioma, and all histological types of the lung cancer cell. Draxin was shown to bind a 22-amino-acid peptide of the EGF domain of Netrin-1, and through Draxin/Netrin-1 interaction, Draxin may act as a secreted Netrin-1 antagonist. C1orf187 can inhibit or repel neurite outgrowth from dorsal spinal cord. It inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway (PMID: 29622850).

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