Anticorps Monoclonal anti-Drebrin

Drebrin Monoclonal Antibody for WB, IHC, ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain, porc, rat, souris

Applications

WB, IHC, ELISA

Conjugaison

Non conjugué

CloneNo.

1A12H1

N° de cat : 67589-1-PBS

Synonymes

DBN1, drebrin 1, Developmentally-regulated brain protein, DBN 1, 1A12H1

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Galerie de données de validation

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  WB analysis using 67589-1-Ig (same clone as 67589-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67589-1-Ig (Drebrin antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67589-1-PBS in a different storage buffer formulation.

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  WB analysis using 67589-1-Ig (same clone as 67589-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67589-1-Ig (Drebrin antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67589-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 67589-1-Ig (same clone as 67589-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 67589-1-Ig (Drebrin antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67589-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67589-1-PBS cible Drebrin dans les applications de WB, IHC, ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

• Réactivité: Humain, porc, rat, souris
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Drebrin Protéine recombinante Ag22635
• Nom complet: drebrin 1
• Poids moléculaire observé: 110-120 kDa
• Numéro d’acquisition GenBank: BC007567
• Symbole du gène: Drebrin
• Identification du gène (NCBI): 1627
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Drebrin (DBN1) is an actin binding and stabilizing protein with roles in endocytosis, formation of dendrite spines in neurons and coordinating cell-cell synapses in immune cells. Preferentially expressed in the brain, it is highly localized in dendritic spines and regulates spine shapes. It has two isoforms that are splice variants, with drebrin A being expressed in neural cells, and drebrin E is present in several other cell types. Recently it has been reported that circulating DBN1 levels correlated with retinal nerve fiber layer defect and may reflect the severity of retinal ganglion cells injury in glaucoma patients.

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