Anticorps Polyclonal de lapin anti-Dysbindin

Dysbindin Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11132-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse brain using 11132-1-AP (same clone as 11132-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 11132-1-AP (Dysbindin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11132-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse testis using 11132-1-AP (same clone as 11132-1-PBS)

  mouse testis tissue were subjected to SDS PAGE followed by western blot with 11132-1-AP (Dysbindin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11132-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human testis using 11132-1-AP (same clone as 11132-1-PBS)

  human testis tissue were subjected to SDS PAGE followed by western blot with 11132-1-AP (Dysbindin antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11132-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 11132-1-AP (same clone as 11132-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 11132-1-AP (Dysbindin antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11132-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 11132-1-AP (same clone as 11132-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 11132-1-AP (Dysbindin antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11132-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11132-1-PBS cible Dysbindin dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Dysbindin Protéine recombinante Ag1613
• Nom complet: dystrobrevin binding protein 1
• Masse moléculaire calculée: 351 aa, 39 kDa
• Poids moléculaire observé: 48 kDa, 36 kDa
• Numéro d’acquisition GenBank: BC011912
• Symbole du gène: Dysbindin
• Identification du gène (NCBI): 84062
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Dysbindin, encoded by DTNBP1 (dystrobrevin binding protein 1), is a synaptic protein which is expressed in diverse neuronal populations throughout the brain. Genetic variation in DTNBP1 is associated with schizophrenia. Reduced expression of dysbindin has been reported in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia cases. Several isoforms of dysbindin exist: 48-50 kDa of dysbindin-1A, 35-38 kDa of dysbindin-1B, and 30-32 kDa of dysbindin-1C. This antibody recognizes all of isoforms of dysbindin. (19617633)

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