Anticorps Polyclonal de lapin anti-EDNRB

EDNRB Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20964-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of HEK-293 using 20964-1-AP (same clone as 20964-1-PBS)

  HEK-293 cells were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse placenta using 20964-1-AP (same clone as 20964-1-PBS)

  mouse placenta tissue were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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  WB analysis of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  human placenta tissue were subjected to SDS PAGE followed by western blot with 20964-1-AP (EDNRB antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 20964-1-AP (EDNRB Antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human placenta using 20964-1-AP (same clone as 20964-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 20964-1-AP (EDNRB Antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 20964-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20964-1-PBS cible EDNRB dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: endothelin receptor type B
• Masse moléculaire calculée: 50 kDa
• Poids moléculaire observé: 53-60 kDa
• Numéro d’acquisition GenBank: NM_000115
• Symbole du gène: EDNRB
• Identification du gène (NCBI): 1910
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

EDNRB (endothelin receptor type B) is a G-protein coupled heptahelical endothelin-1 (EDN1) receptor. EDN1, a known mediator of human myometrial contraction in vitro, belongs to a family of three 21-amino acid isopeptides (PMID:18497345). EDNRB is a 442-residue protein expressed post-natally in many tissues, particularly in the myenteric plexus, mucosal layer, ganglia, and blood vessels of the submucosa of the colon (PMID:11434563). Moreover, Both the EDNRA and EDNRB are expressed in ships and can be bound by EDN1. Still, while EDNRA mediates a constrictive effect, EDNRB is involved in vasorelaxation and functions as a clearance receptor that scavenges circulating EDN1 (PMID:30171849).

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