Anticorps Monoclonal anti-Endoglin/CD105

Endoglin/CD105 Monoclonal Antibody for IF/ICC, Cytometric bead array, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

IF/ICC, Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2D4A5

N° de cat : 68748-2-PBS

Synonymes

CD105, 2D4A5, HHT1, ENG, Endoglin

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Galerie de données de validation

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  IF Staining of HUVEC using 68748-2-Ig (same clone as 68748-2-PBS)

  Immunofluorescent analysis of un-fixed HUVEC cells using Endoglin/CD105 antibody (68748-2-Ig, Clone: 2D4A5 ) at dilution of 1:1422 and Multi-rAb CoraLite® Plus 594-Goat Anti-Mouse Recombinant Secondary Antibody (H+L) (Cat.NO. RGAM004 ). This data was developed using the same antibody clone with 68748-2-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP50103-1

  Cytometric bead array standard curve of MP50103-1, ENG Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 68748-1-PBS. Detection antibody: 68748-2-PBS. Standard:Eg0587. Range: 0.391-100 ng/mL.

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Informations sur le produit

68748-2-PBS cible Endoglin/CD105 dans les applications de IF/ICC, Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: endoglin
• Masse moléculaire calculée: 71 kDa
• Numéro d’acquisition GenBank: BC014271
• Symbole du gène: CD105
• Identification du gène (NCBI): 2022
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)

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