Anticorps Polyclonal de lapin anti-EPDR1

EPDR1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27252-1-PBS

Synonymes

EPDR, Mammalian ependymin-related protein 1, MERP 1, MERP1, MERP-1

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Galerie de données de validation

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  WB analysis using 27252-1-AP (same clone as 27252-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27252-1-AP (EPDR1 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27252-1-PBS in a different storage buffer formulation.

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  IHC staining of human stomach using 27252-1-AP (same clone as 27252-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 27252-1-AP (EPDR1 antibody) at dilution of 1:2000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27252-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27252-1-PBS cible EPDR1 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: EPDR1 Protéine recombinante Ag26120
• Nom complet: Mammalian ependymin-related protein 1
• Masse moléculaire calculée: 25 kDa
• Poids moléculaire observé: 25-30 kDa
• Numéro d’acquisition GenBank: BC018299
• Symbole du gène: EPDR1
• Identification du gène (NCBI): 54749
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The ependymin-related 1 (EPDR1) gene, also known as MERP1 and UCC1, encodes for a protein related to ependymins, which are type II transmembrane proteins that are similar to two families of cell adhesion molecules: the protocadherins and ependymins. Ependymin-related protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat. Proteomics studies of mammalian mannose-6-phosphate (M6P) glycoproteins have identified EPDR1 as a lysosomal protein with unknown function. The lysosomal localization of EPDR1 was further demonstrated in mouse brain homogenates by subcellular fractionation.(PMID: 36343918, PMID: 33902536, PMID: 30729188)

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