Anticorps Monoclonal anti-ERC1

ERC1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2A5B9

N° de cat : 66681-1-PBS

Synonymes

Cast2, ELKS, ERC 1, ERC1, KIAA1081, Rab6 interacting protein 2, RAB6IP2

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Galerie de données de validation

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  WB analysis using 66681-1-Ig (same clone as 66681-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 66681-1-Ig (ERC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66681-1-PBS in a different storage buffer formulation.

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Informations sur le produit

66681-1-PBS cible ERC1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: ERC1 Protéine recombinante Ag17665
• Nom complet: ELKS/RAB6-interacting/CAST family member 1
• Masse moléculaire calculée: 1116 aa, 128 kDa
• Poids moléculaire observé: 135 kDa
• Numéro d’acquisition GenBank: BC132782
• Symbole du gène: ERC1
• Identification du gène (NCBI): 23085
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ERC is an acronym based on previous separate namings of members of this protein family, ELKS, Rab6IP2 and CAST (PMID: 12391317). They are known to bind RIMs, the active zone proteins that regulate neurotransmitter release. ERC1 (ELKS) is an essential regulatory subunit of the IKK complex and likely functions by recruiting IκBα to the complex (PMID: 15218148). Multiple isoforms of ERC1 mRNA are generated by alternative splicing (PMID: 12203787). There are two known splice variants of ERC1 protein that differ at their C termini, ERC1a and ERC1b. ERC1a is ubiquitously expressed, whereas ERC1b is brain-specific (PMID: 12391317; 12923177).

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