Anticorps Polyclonal de lapin anti-ERCC8

ERCC8 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 15921-1-PBS

Synonymes

CKN1, CSA, DNA excision repair protein ERCC-8, ERCC Excision Repair 8, CSA Ubiquitin Ligase Complex Subunit

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Galerie de données de validation

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  WB analysis using 15921-1-AP (same clone as 15921-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 15921-1-AP (ERCC8 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15921-1-PBS in a different storage buffer formulation.

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Informations sur le produit

15921-1-PBS cible ERCC8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ERCC8 Protéine recombinante Ag8734
• Nom complet: excision repair cross-complementing rodent repair deficiency, complementation group 8
• Masse moléculaire calculée: 396 aa, 44 kDa
• Poids moléculaire observé: 42 kDa
• Numéro d’acquisition GenBank: BC009793
• Symbole du gène: ERCC8
• Identification du gène (NCBI): 1161
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ERCC8 (also known as Cockayne Syndrome A protein, CSA) is a critical nuclear protein that serves as a specific adapter component of the CRL4ᴱᴿᶜᶜ⁸ ubiquitin ligase complex. Its primary function is to play a central role in the transcription-coupled nucleotide excision repair pathway, specifically recognizing and repairing the template strands of actively transcribed genes damaged by factors such as ultraviolet radiation. Mutations in the ERCC8 gene cause Cockayne syndrome, an autosomal recessive disorder characterized by severe photosensitivity, premature aging, neurodevelopmental abnormalities, and sensorineural hearing loss. This demonstrates that ERCC8 is essential for maintaining transcriptional fidelity, neuronal survival, and combating oxidative stress. Therefore, ERCC8 is not only a key factor in DNA repair but also an important molecule for studying mechanisms of premature aging and neurobiology.

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